HCID 89962862, compound → HCID 89963119, compound

HRID 337868Notes

Reaction equation

HRID 337868 reaction equation
[CH3:1][C:2]1([CH3:14])[CH2:6][C:5](=[O:7])[C:4]([C:8]2[N:12]([CH3:13])[N:11]=[CH:10][CH:9]=2)=[CH:3]1>C(O)C.[C].[Pd]>[CH3:1][C:2]1([CH3:14])[CH2:6][C:5](=[O:7])[CH:4]([C:8]2[N:12]([CH3:13])[N:11]=[CH:10][CH:9]=2)[CH2:3]1

Participants

4

Reactant 1

HCID 89962862HCID 89962862, compound

Product 1

HCID 89963119HCID 89963119, compoundYield 95.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of the 4,4-dimethyl-2-(1-methyl-1H-pyrazol-5-yl)cyclopent-2-en-1-one (780 mg, 4.10 mmol) prepared in Example 93c and palladium carbon (5%; 700 mg) in ethanol (8.0 mL) was stirred for 6 hours under a hydrogen atmosphere. The reaction solution was filtered through celite to yield the title compound (750 mg, 95%) in a crude form as a yellow oil.

Workup

  1. filtrationThe reaction solution was filtered through celite

Sources & evidence

ORD record
ord-b5f93f249afd4cb89b669098da7d97e5
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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