HCID 89962265, compound → HCID 89962137, compound

HRID 337899Notes

Reaction equation

HRID 337899 reaction equation
[C:1]([O:9][C@H:10]1[CH2:14][C@@H:13]([O:15]CC2C=CC=CC=2)[CH2:12][C@@H:11]1[C:23]1[N:27]([CH3:28])[N:26]=[CH:25][CH:24]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[C].[Pd].C(O)C>[C:1]([O:9][C@H:10]1[CH2:14][C@@H:13]([OH:15])[CH2:12][C@@H:11]1[C:23]1[N:27]([CH3:28])[N:26]=[CH:25][CH:24]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 89962265HCID 89962265, compound

Product 1

HCID 89962137HCID 89962137, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 106b by using the (1S*,2R*,4S*)-4-(benzyloxy)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentyl benzoate (297 mg, 0.789 mmol) prepared in Example 107a, palladium carbon (5%; 300 mg) and ethanol (3.0 mL), to yield the title compound (205 mg, 91%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-7783a17c9f334a0e8b86b0dd2ab7ba28
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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