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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 337911Generated: October 25, 2026

Potassium Carbonate → HCID 89963326, compound

https://huagongshe.com/reaction/337911

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant2,4-DifluoropyrimidineHCID 137716—
ReactantHCID 89963518HCID 89963518—
SolventDimethylformamideHCID 6228—
ProductHCID 89963326HCID 8996332670.2%

Reaction Steps

The reaction and aftertreatment were conducted in the same manner as in Example 111d by using the 2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentyl]oxy}benzenesulfonamide (0.16 g, 0.47 mmol) prepared in Example 114c, 2,4-difluoropyrimidine (0.16 g, 1.41 mmol), potassium carbonate (0.26 g, 1.88 mmol) and DMF (4.7 mL), to yield the title compound (143.6 mg, 70%) as a colorless amorphous solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889741B2
Source datasetuspto-grants-2014_11
ORD IDord-d65347fd72d34332b2542c5cfc22c51f
Source noteuspto-grants-2014_11