HCID 89961757, compound → HCID 89962434, compound

HRID 337916Notes

Reaction equation

HRID 337916 reaction equation
[C:1]([O:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([O:16]CC2C=CC=CC=2)[C@@H:11]1[C:24]1[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[C].[Pd].C(O)C>[C:1]([O:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([OH:16])[C@@H:11]1[C:24]1[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 89961757HCID 89961757, compound

Product 1

HCID 89962434HCID 89962434, compoundYield 43.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 106b by using the (1S*,2S*,3R*)-3-(benzyloxy)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl benzoate (1.81 g, 4.64 mmol) prepared in Example 117a, palladium carbon (5%; 1.80 g) and ethanol (20 mL), to yield the title compound (600 mg, 43%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-77e04fc0aa7f4ee798e0f7df471f614d
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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