Water → HCID 89962992, compound

HRID 337931Notes

Reaction equation

HRID 337931 reaction equation
[C:1]1([C:7]2[N:11]([CH3:12])[N:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.CS(N)(=O)=[O:15].C(O)(C)(C)C.[OH2:23]>>[CH3:12][N:11]1[C:7]([C@@:1]2([OH:15])[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]2[OH:23])=[CH:8][CH:9]=[N:10]1

Participants

5

Reactant 4

HCID 962WaterHCID 6386tert-ButanolHCID 72879MethanesulfonamideHCID 89963215HCID 89963215, compound

Product 1

HCID 89962992HCID 89962992, compoundYield 99%

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 102a by using the 5-(cyclohex-1-en-1-yl)-1-methyl-1H-pyrazole (2.66 g, 16.4 mmol) prepared in Example 123b, methanesulfonamide (1.56 g, 16.4 mmol), t-butanol (20 mL), water (20 mL) and AD-mixα (Sigma-Aldrich Corp.; 23.0 g), to yield the title compound (3.22 g, 99%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-9f49611ad6a34591b510f0026ca506fc
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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