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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 337964Generated: October 27, 2026

(1S*,2R*)-5,5-Difluoro-2-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]cyclohexanol → (1R,2S)-5,5-Difluoro-2-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]cyclohexanol

https://huagongshe.com/reaction/337964

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1S*,2R*)-5,5-Difluoro-2-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]cyclohexanolHCID 89963182—
SolventIsopropanol hexaneHCID 21585144—
Product(1R,2S)-5,5-Difluoro-2-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]cyclohexanolHCID 89963210—

Reaction Steps

The (1S*,2R*)-5,5-difluoro-2-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]cyclohexanol prepared in Example 143d was optically resolved with CHIRALPAK IA (Daicel Corp.; hexane/isopropanol=8:2) to yield the title compound as a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889741B2
Source datasetuspto-grants-2014_11
ORD IDord-716d529bdb674f2aa8db09c7254a377e
Source noteuspto-grants-2014_11