HCID 89962682, compound → HCID 89962896, compound

HRID 337997Notes

Reaction equation

HRID 337997 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][N:7]1[C:11]([C@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@@H:13]2[OH:18])=[CH:10][CH:9]=[N:8]1>CCCCCC.C(O)(C)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][N:7]1[C:11]([C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[OH:18])=[CH:10][CH:9]=[N:8]1

Participants

3

Reactant 1

HCID 89962682HCID 89962682, compound

Product 1

HCID 89962896HCID 89962896, compound

Reagents, catalysts & solvents 1

HCID 21585144Isopropanol hexaneSolvent

Procedure

The (1S*,2R*)-2-{1-[(2-methoxyethoxy)methyl]-1H-pyrazol-5-yl}cyclohexanol prepared in Example 158a was optically resolved with CHIRALFLASH IC (Daicel Corp.; hexane/isopropanol=1:1) to yield the title compound as a colorless oil.

Sources & evidence

ORD record
ord-7736ba10591545ee8c9d87a7004c62d3
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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