Sodium Hydroxide → HCID 59797443, compound

HRID 33800Notes

Reaction equation

HRID 33800 reaction equation
C[O:2][C:3](=[O:33])[CH2:4][O:5][C:6]1[C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[S:11][C:10]=2[C:9]([C:20]2[O:21][C:22]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:23][C:24](=[O:26])[CH:25]=2)=[CH:8][CH:7]=1.[OH-].[Na+:35]>CO>[Na+:35].[N:27]1([C:22]2[O:21][C:20]([C:9]3[C:10]4[S:11][C:12]5[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=5)[S:18][C:19]=4[C:6]([O:5][CH2:4][C:3]([O-:33])=[O:2])=[CH:7][CH:8]=3)=[CH:25][C:24](=[O:26])[CH:23]=2)[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59797432[4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-1-yloxy]-acetic acid methyl ester

Product 1

HCID 59797443HCID 59797443, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-1-yloxy]-acetic acid methyl ester (1.41 g, 2.91 mmol) in anhydrous methanol (10 ml) was added sodium hydroxide (120 mg, 2.91 mmol) in a single portion. The solution was then stirred at room temperature for 24 hours whereupon the solvent was removed in vacuo to give the title compound as an off white paste (1.43 g, 98%) that required no further purification. m/z (LC-MS, ESP): RT=3.79 min, (M−−23)=468

Workup

  1. customwas removed in vacuo

Sources & evidence

ORD record
ord-e52a91aebc534d4dacbd50f3f2e5e93f
Source dataset
uspto-grants-2008_09
Patent number
US07429660B2

Reaction notes

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