HCID 89962282, compound → HCID 89962478, compound

HRID 338036Notes

Reaction equation

HRID 338036 reaction equation
[NH:1]1[CH:5]=[C:4]([C@@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[OH:12])[CH:3]=[N:2]1>CCCCCC.C(O)C>[NH:1]1[CH:5]=[C:4]([C@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]2[OH:12])[CH:3]=[N:2]1

Participants

3

Reactant 1

HCID 89962282HCID 89962282, compound

Product 1

HCID 89962478HCID 89962478, compound

Reagents, catalysts & solvents 1

HCID 21879635Ethanol hexaneSolvent

Procedure

The (1R*,2S*)-2-(1H-pyrazol-4-yl)cyclohexanol prepared in Example 169a was optically resolved with CHIRALPAK AD-H (Daicel Corp.; hexane/ethanol=8:2) to yield the title compound as a colorless solid.

Sources & evidence

ORD record
ord-ab7cde65aab04395ba9643091c101d2b
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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