反应详情

A solution of benzyl N-allyl-N-(2,2-dimethoxyethyl)carbamate (30 g, 107 mmol) in formic acid (36.8 mL, 860 mmol) and water (4.84 mL) is stirred at room temperature overnight. The mixture is concentrated and diluted with hexanes/ethyl acetate (1:2) and water. The organic layer is separated, washed with brine solution until pH=6, and dried over sodium sulfate. The solvent is evaporated to give the title compound (25 g, 99%). ES/MS (m/e): 234 (M+H).

1. concentrationThe mixture is concentrated
2. additiondiluted with hexanes/ethyl acetate (1:2) and water
3. customThe organic layer is separated
4. washwashed with brine solution until pH=6
5. dry with materialdried over sodium sulfate
6. customThe solvent is evaporated