Sodium Hydroxide → [6-(6-Morpholin-4-yl-4-oxo-4h-pyran-2-yl)-thianthren-2-yloxy]-acetic acid sodium salt

HRID 33810Notes

Reaction equation

C[O:2][C:3](=[O:33])[CH2:4][O:5][C:6]1[CH:19]=[CH:18][C:17]2[S:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[C:20]3[O:21][C:22]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:23][C:24](=[O:26])[CH:25]=3)[S:9][C:8]=2[CH:7]=1.[OH-].[Na+:35]>CO>[Na+:35].[N:27]1([C:22]2[O:21][C:20]([C:14]3[CH:13]=[CH:12][CH:11]=[C:10]4[C:15]=3[S:16][C:17]3[CH:18]=[CH:19][C:6]([O:5][CH2:4][C:3]([O-:33])=[O:2])=[CH:7][C:8]=3[S:9]4)=[CH:25][C:24](=[O:26])[CH:23]=2)[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of [6-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-2-yloxy]-acetic acid methyl ester (22 mg, 0.045 mmol in methanol (2 ml) was added solid sodium hydroxide (2 mg, 0.045 mmol). The mixture was stirred vigorously and heated to 60° C. for 1 hour. After this time, the mixture was concentrated in vacuo to dryness to give the title compound (22.4 mg, 100%) and used without any further purification.

Workup

concentrationAfter this time, the mixture was concentrated in vacuo to dryness

Sources & evidence

ORD record: ord-421a9042b0ea455fbde065aacad99652
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429660B2

Reaction notes

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