Hydrochloric Acid → (4aR,7aS)-6-(5-Fluoropyrimidin-2-yl)-7a-phenyl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine hydrochloride

Participants

Reaction Steps

A solution of hydrogen chloride (1 M in diethyl ether) (17 mL, 17 mmol) is added to a solution of (4aR,7aS)-6-(5-fluoropyrimidin-2-yl)-7a-phenyl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine (4.6 g, 14 mmol) in ethyl acetate (46 mL) and stirred for one hour. The solvent is removed under vacuum to give the title compound (5 g, 98%). ES/MS (m/e): 330 (M+H).

Provenance & Evidence