HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 338348Generated: October 29, 2026
Ethyl Acetate → 1-(3-(4-Bromophenoxy)propyl)-4-methylpiperazine
https://huagongshe.com/reaction/338348
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-Bromo-4-(3-bromopropoxy)benzene | HCID 347924 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(3-(4-Bromophenoxy)propyl)-4-methylpiperazine | HCID 4995096 | 87.6% |
Reaction Steps
To a mixture of 1-bromo-4-(3-bromopropoxy)benzene (300 mg, 1.02 mmol) and 1-methylpiperazine (100 mg, 1.02 mmol) in CH3CN (6 mL) was added Cs2CO3 (365 mg, 1.10 mmol). The mixture was stirred at 75° C. for 5 hours. The mixture was poured into ethyl acetate and washed with water. The organic phase was dried over sodium sulfate, filtered, and concentrated to give the title compound (280 mg, 75% yield) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08889730B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-b7223641ab914dc2a3d0b7b1c2b1b997 |
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| Source note | uspto-grants-2014_11 |
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