2-[4-(2-Methyl-6-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-7-yl)-phenoxymethyl]-quinoline → 2-[4-(2-Methyl-6-pyridin-4-yl-[1,2,4]triazolo[1.5-a]pyrimidin-7-yl)-phenoxymethyl]-quinoline

HRID 33837Notes

Reaction equation

HRID 33837 reaction equation
C[C:2]1[CH:34]=[C:5]2[N:6]=[CH:7][C:8]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)=[C:9]([C:10]3[CH:27]=[CH:26][C:13]([O:14][CH2:15][C:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[N:17]=4)=[CH:12][CH:11]=3)[N:4]2[N:3]=1.CC1[N:37]=C(N)NN=1>>[CH3:34][C:2]1[N:37]=[C:5]2[N:6]=[CH:7][C:8]([C:28]3[CH:29]=[CH:30][N:31]=[CH:32][CH:33]=3)=[C:9]([C:10]3[CH:27]=[CH:26][C:13]([O:14][CH2:15][C:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[N:17]=4)=[CH:12][CH:11]=3)[N:4]2[N:3]=1

Participants

3

Reactant 2

HCID 116622252-[4-(2-Methyl-6-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-7-yl)-phenoxymethyl]-quinolineHCID 178434684HCID 178434684, compound

Product 1

HCID 115250912-[4-(2-Methyl-6-pyridin-4-yl-[1,2,4]triazolo[1.5-a]pyrimidin-7-yl)-phenoxymethyl]-quinoline

Procedure

Following the procedure for the preparation of 2-[4-(2-Methyl-6-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-7-yl)-phenoxymethyl]-quinoline but substituting 5-Methyl-2H-[1,2,4]-triazol-3ylamine provided the title compound. 1H NMR (400 MHz, CDCl3) δ 8.75 (s, 1H), 8.55 (m, 2H), 8.21(d, J=8.3 Hz, 1 H), 8.06 (d, J=7.5 Hz, 1H), 7.84 (d, J=7.1 Hz, 1H), 7.73 (m, 1H), 7.64 (d, J=8.3 Hz, 1 H), 7.55 (m, 1H), 7.42 (d, J=8.7, 2H), 7.08 (m, 4H), 5.39 (s, 2H) 2.60 (s, 3H); MS: (M+H m/z=445.2).

Sources & evidence

ORD record
ord-25d64251bb2a481390fb8436ddb4bb7f
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Reaction notes

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