7-Chloro-2-(chloromethyl)quinoline → 7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride

Participants

Role	Name	HCID	Charge
Reactant	7-Chloro-2-(chloromethyl)quinoline	HCID 10954844	—
Reactant	Methyl 4-(2-quinolinylmethoxy)benzoate	HCID 19934817	—
Reactant	4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]Phenol	HCID 135915213	—
Product	7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride	HCID 11561731	—

Reaction Steps

Following the procedure for the preparation of 4-(Quinolin-2-ylmethoxy)-benzoic acid methyl ester but substituting 4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenol and 7-chloro-2-chloromethyl-quinoline provided the title compound. 1H NMR (400 MHz, DMSO) δ 8.66 (d, J=6.6 Hz, 2H), 8.54 (s, 1 H), 8.47 (d, J=8.3, 2H), 8.04 (m, 2H), 7.70 (m, 2H), 7.65 (m, 1H), 7.36 (d, J=8.7 Hz, 2H), 7.12 (d, J=8.7, 2H), 5.38 (s, 2H), 3.90 (s, 3 H); MS: (M+H m/z=427.1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07429665B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-691d24d58cb347c197930b510ed1a33c
Source note	uspto-grants-2008_09