反应详情

A mixture of 4-bromo-2-fluorobenzaldehyde (25.0 g, 0.123 mol) and sodium methoxide (13.99 g, 0.2600 mol) in dry methanol (250 mL) was stirred at reflux temperature for 16 hours. The mixture was concentrated and the residue was partitioned between dichloromethane (500 mL) and water (250 mL). The organic layers were combined and dried over sodium sulfate then concentrated in vacuo to provide the title compound as yellow solid (25 g, 94.5%).

1. temperatureat reflux temperature for 16 hours
2. concentrationThe mixture was concentrated
3. customthe residue was partitioned between dichloromethane (500 mL) and water (250 mL)
4. dry with materialdried over sodium sulfate
5. concentrationthen concentrated in vacuo