1-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamide → 1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(2,6-dichlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide

HRID 338583ノート

反応式

HRID 338583 の反応式
O1C2C=CC(C3(C(NC4C=CC(CC5C=CC=CC=5)=CN=4)=O)CC3)=CC=2OC1.[O:29]1[C:33]2[CH:34]=[CH:35][C:36]([C:38]3([C:41]([NH:43][C:44]4[CH:49]=[CH:48][C:47](Br)=[CH:46][N:45]=4)=[O:42])[CH2:40][CH2:39]3)=[CH:37][C:32]=2[O:31][CH2:30]1.[Cl-].[Cl:52][C:53]1[CH:60]=[CH:59][CH:58]=[C:57]([Cl:61])[C:54]=1[CH2:55][Zn+]>>[O:29]1[C:33]2[CH:34]=[CH:35][C:36]([C:38]3([C:41]([NH:43][C:44]4[CH:49]=[CH:48][C:47]([CH2:55][C:54]5[C:53]([Cl:52])=[CH:60][CH:59]=[CH:58][C:57]=5[Cl:61])=[CH:46][N:45]=4)=[O:42])[CH2:40][CH2:39]3)=[CH:37][C:32]=2[O:31][CH2:30]1

参加物

4

反応物 3

HCID 578951641-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamideHCID 591661631-(benzo[d][1,3]dioxol-5-yl)-N-(5-bromopyridin-2-yl)cyclopropanecarboxamideHCID 178478101HCID 178478101、化合物

生成物 1

HCID 442365001-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(2,6-dichlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide

実験手順

1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(2,6-dichlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide was synthesized using the procedure of 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamide by reacting 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-bromopyridin-2-yl)cyclopropanecarboxamide with (2,6-dichlorobenzyl)zinc(II) chloride.

出典と根拠

ORDレコード
ord-f38c2147faf6452e9136f5ad8c85f3a5
出典データセット
uspto-grants-2014_11
特許番号
US08889875B2

反応ノート

読み込み中…