Hydrochloric Acid → HCID 67078752, compound

Participants

Reaction Steps

Dissolving 3-pyridylacrylic acid (1.49 g, 10 mmol) and HBTU (3.79 g, 10 mmol) into 10 ml of acetonitrile, drop-adding triethylamine (2.02 g, 20 mmol), stirring at room temperature 30 minutes, to obtain a yellow sticky liquid. Dissolving p-aminobenzoic acid (1.52 g, 10 mmol) in 10 ml of 1 mol/L sodium hydroxide aqueous solution, and thereto drop-adding the above yellow sticky liquid at 60° C. After completion of drop-addition, maintaining the temperature for 1 hour to complete the reaction. The reaction solution is adjusted to pH of about 7 with concentrated hydrochloric acid. Large amount of solids are precipitated, filtrated and dried to obtain 1.90 g of 4-[(3-pyridylacryloyl)aminomethyl]benzoic acid (intermediate M-20) as a white solid, with a yield of 67.6%.

Provenance & Evidence