反应详情

温度

20 °C

A mixture of (1S,4S)-5-(2-hydroxyethyl)-2-thia-5-azabicyclo[2.2.1]heptane 2,2-dioxide (80 mg, 0.418 mmol) and thionyl chloride (0.153 mL, 2.092 mmol) in dichloromethane (2 mL) was stirred at 20° C. for 16 hours. The reaction mixture was concentrated under reduced pressure to provide the title compound (90 mg, 87% yield) as a yellow solid. LCMS: m/e 210.02 (M+H)+, 1.76 min (method 2).

1. concentrationThe reaction mixture was concentrated under reduced pressure