Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 반응물 | 4-(2-Quinolin-2-yl-ethyl)-benzoic acid | HCID 68576307 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide | HCID 86249320 | 88% |
반응 단계
To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429665B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-6d3e54542bd0421ba53f0b6ecb57c14b |
| 출처 메모 | uspto-grants-2008_09 |