HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Amino-2-Ethyl-alpha-oxo-1-(phenylmethyl)-1H-indole-3-Acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-(1-Benzyl-2-ethyl-4-nitro-1H-indol-3-yl)-2-oxo-acetamide | HCID 10641658 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Amino-2-Ethyl-alpha-oxo-1-(phenylmethyl)-1H-indole-3-Acetamide | HCID 10758122 | 30.2% |
Reaction Steps
A solution of 6.0 g (17.1 mmol) of 2-Ethyl-4-Nitro-α-oxo-1-(phenylmethyl)-1H-indole-3-acetamide in 140 ml of 1:1 THF:EtOH containing 1,0 g of 5% Pt/BaSO4 was hydrogenated at room temperature and 60 psi (4.22 Kg/cm2) for four hours. The catalyst was filtered and the filtrate evaporated in vacuo. The residue was chromatographed over silica gel eluting with Hexane/50 to 100% EtOAC to give 1.66 g (30%) of 4-Amino-2-Ethyl-α-oxo-1-(phenylmethyl)-1H-indole-3-Acetamide melting at 140°-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733923 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-530aa127a76e4169b9ca650bd1dc8905 |
| Source note | uspto-grants-1998_03 |