2-{2-[4-(4-Pyridin-4-yl-2H-pyrazol-3-yl)-phenyl]-ethyl}-quinoline → HCID 178477883, compound

HRID 33870Notes

Reaction equation

HRID 33870 reaction equation
N1C=CC(C2C=[N:10][NH:9][C:8]=2C2C=CC(CCC3C=CC4C(=CC=CC=4)N=3)=CC=2)=CC=1.[Cl:30][C:31]1[CH:36]=[C:35]([CH2:37][C:38]([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]3[CH:57]=[CH:56][C:55]4[C:50](=[CH:51][CH:52]=[CH:53][CH:54]=4)[N:49]=3)=[CH:42][CH:41]=2)=O)[CH:34]=[CH:33][N:32]=1>>[Cl:30][C:31]1[CH:36]=[C:35]([C:37]2[C:38]([C:40]3[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]4[CH:57]=[CH:56][C:55]5[C:50](=[CH:51][CH:52]=[CH:53][CH:54]=5)[N:49]=4)=[CH:42][CH:41]=3)=[N:10][NH:9][CH:8]=2)[CH:34]=[CH:33][N:32]=1

Participants

3

Reactant 2

HCID 115670052-{2-[4-(4-Pyridin-4-yl-2H-pyrazol-3-yl)-phenyl]-ethyl}-quinolineHCID 862493242-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone

Product 1

HCID 178477883HCID 178477883, compound

Procedure

Following the procedure for the preparation of 2-{2-[4-(4-Pyridin4-yl-2H-pyrazol-3-yl)-phenyl]-ethyl}-quinoline but substituting 2-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone provided the title compound. 1H NMR (400 MHz, CDCl3) δ 8.23 (m, 2 H), 8.08 (d, J=8.7 Hz, 1 H), 7.83 (d, J=8.3 Hz, 1 H), 7.80 (s, 1H), 7.75 (t, J=7.1 Hz, 1 H), 7.67 (d, J=8.3 Hz, 1H), 7.57 (t, J=7.1 Hz, 1 H), 7.33 (d, J=9.1 Hz, 2H), 7.05 (m, 4H), 5.40 (s, 2H); MS: (M+H m/z=413.1).

Sources & evidence

ORD record
ord-7e81ccc64a5c4395b97ebb9c614ed3d1
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Reaction notes

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