3-(Trifluoromethyl)aniline → 4-Pyridinecarboxamide, 2-bromo-N-[3-(trifluoromethyl)phenyl]-

HRID 338716Notes

Reaction equation

HRID 338716 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[F:11][C:12]([F:21])([F:20])[C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:16][C:15]1[CH:17]=[CH:18][CH:19]=[C:13]([C:12]([F:11])([F:20])[F:21])[CH:14]=1)=[O:7]

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 2227012-Bromoisonicotinic acid

Product 1

HCID 866958424-Pyridinecarboxamide, 2-bromo-N-[3-(trifluoromethyl)phenyl]-

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and 3-trifluoromethylaniline were converted to the title compound

Sources & evidence

ORD record
ord-35e26f55e3eb4c8b9a795eb56ca0f356
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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