2-Bromoisonicotinic acid → 2-Bromo-N-(3-isopropyl-phenyl)-isonicotinamide

HRID 338717Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[CH:11]([C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17])([CH3:13])[CH3:12]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:17][C:16]1[CH:18]=[CH:19][CH:20]=[C:14]([CH:11]([CH3:13])[CH3:12])[CH:15]=1)=[O:7]

Participants

Reactant 2

HCID 2227012-Bromoisonicotinic acid

HCID 4586793-Isopropylaniline

Product 1

HCID 866958432-Bromo-N-(3-isopropyl-phenyl)-isonicotinamide

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and 3-isopropylaniline were converted to the title compound

Sources & evidence

ORD record: ord-1e98347cb87044349b9c6116a9b9c62d
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889870B2

Reaction notes

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