2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine → N-(3-methylphenyl)-2-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]isonicotinamide

HRID 338720Notes

Reaction equation

HRID 338720 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][N:29]=1)[C:17]([NH:19][C:20]1[CH:21]=[C:22]([CH3:26])[CH:23]=[CH:24][CH:25]=1)=[O:18]>>[CH3:26][C:22]1[CH:21]=[C:20]([NH:19][C:17](=[O:18])[C:16]2[CH:15]=[CH:14][N:29]=[C:28]([N:11]3[CH2:10][CH2:9][C:7]4[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=4[CH2:12]3)[CH:27]=2)[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 552636702-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidineHCID 866958412-Bromo-N-m-tolyl-isonicotinamide

Product 1

HCID 86695846N-(3-methylphenyl)-2-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]isonicotinamide

Procedure

In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 2-bromo-N-m-tolyl-isonicotinamide were converted to the title compound.

Sources & evidence

ORD record
ord-a8bbfa1e9daf462fa20bef2ff50e131c
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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