2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine → N-(4-Isopropyl-phenyl)-2-(2-methylsulfanyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-isonicotinamide

HRID 338723Notes

Reaction equation

HRID 338723 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[C:16]([CH:29]=[CH:30][N:31]=1)[C:17]([NH:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=1)=[O:18]>>[CH:26]([C:23]1[CH:22]=[CH:21][C:20]([NH:19][C:17](=[O:18])[C:16]2[CH:15]=[CH:14][N:31]=[C:30]([N:11]3[CH2:10][CH2:9][C:7]4[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=4[CH2:12]3)[CH:29]=2)=[CH:25][CH:24]=1)([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 552636702-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidineHCID 866958442-Bromo-N-(4-isopropyl-phenyl)-isonicotinamide

Product 1

HCID 86695849N-(4-Isopropyl-phenyl)-2-(2-methylsulfanyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-isonicotinamide

Procedure

In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 2-bromo-N-(4-isopropyl-phenyl)-isonicotinamide were converted to the title compound.

Sources & evidence

ORD record
ord-f9e84e1b2b3e463596883c9f712aa910
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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