2-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidine → 4-(2-Methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

HRID 338731Notes

Reaction equation

HRID 338731 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1.Br[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)=[O:20])[CH:14]=1>>[F:31][C:28]([F:29])([F:30])[C:25]1[CH:24]=[CH:23][C:22]([NH:21][C:19]([C:15]2[CH:14]=[C:13]([N:10]3[CH2:11][C:6]4[CH:5]=[N:4][C:3]([S:2][CH3:1])=[N:8][C:7]=4[CH2:9]3)[CH:18]=[CH:17][N:16]=2)=[O:20])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 670658482-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidineHCID 866958514-Bromo-N-(4-(trifluoromethyl)phenyl)picolinamide

Product 1

HCID 866958554-(2-Methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

Procedure

In a manner similar to that describe in Example 126, 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine and 4-Bromo-N-(4-(trifluoromethyl)phenyl)picolinamide were converted to the title compound.

Sources & evidence

ORD record
ord-ab6ededa17724c9caf9e00943211f580
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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