3-Bromo-3'-(trifluoromethyl)benzanilide → 3-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide

HRID 338735Notes

Reaction equation

HRID 338735 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1.Br[C:13]1[CH:14]=[C:15]([CH:29]=[CH:30][CH:31]=1)[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=1)=[O:17]>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][N:10]([C:13]3[CH:14]=[C:15]([CH:29]=[CH:30][CH:31]=3)[C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)=[O:17])[CH2:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 7638833-Bromo-3'-(trifluoromethyl)benzanilideHCID 670658482-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidine

Product 1

HCID 717356893-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide

Procedure

In a manner similar to that describe in Example 126, 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine and 3-Bromo-N-[3-(trifluoromethyl)phenyl]benzamide were converted to the title compound.

Sources & evidence

ORD record
ord-0ed4df401dd54c72a1ed9dbbdf998354
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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