3-bromo-N-(3-isopropylphenyl)benzamide → N-(3-isopropylphenyl)-3-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]benzamide

HRID 338736Notes

Reaction equation

HRID 338736 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1.Br[C:13]1[CH:14]=[C:15]([CH:28]=[CH:29][CH:30]=1)[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]([CH3:27])[CH3:26])[CH:20]=1)=[O:17]>>[CH:25]([C:21]1[CH:20]=[C:19]([NH:18][C:16](=[O:17])[C:15]2[CH:28]=[CH:29][CH:30]=[C:13]([N:10]3[CH2:11][C:6]4[CH:5]=[N:4][C:3]([S:2][CH3:1])=[N:8][C:7]=4[CH2:9]3)[CH:14]=2)[CH:24]=[CH:23][CH:22]=1)([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 288260133-bromo-N-(3-isopropylphenyl)benzamideHCID 670658482-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidine

Product 1

HCID 71735690N-(3-isopropylphenyl)-3-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]benzamide

Procedure

In a manner similar to that describe in Example 126, 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine and 3-bromo-N-(3-isopropylphenyl)benzamide were converted to the title compound.

Sources & evidence

ORD record
ord-75aeb1d0f19a4865b82e19a4c4111a48
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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