Hydrochloric Acid → 6-Bromo-5,5,6,6-tetrafluorohexanoic acid

Participants

Reaction Steps

7000 g (26.4 mol) of 15% of sodium hydroxide aqueous solution was added to 1940 g (5.29 mol) of the objective 2-(4-bromo-3,3,4,4-tetrafluorobutyl)-malonic acid diethyl ester obtained as discussed above, followed by refluxing it for 2 hours. Upon cooling it to room temperature, 2900 g (29.1 mol) of concentrated hydrochloric acid (36%) is added in an iced bath, followed by extraction with diisopropyl ether. A residue obtained by distilling a solvent off was heated to 170° C. thereby obtaining 1338 g of the objective 6-bromo-5,5,6,6-tetrafluorohexanoic acid (95% yield) in the form of a brown liquid.

Provenance & Evidence