Thionyl Chloride → 6-Bromo-5,5,6,6-tetrafluorohexanoyl chloride

Participants

Reaction Conditions

Reaction Steps

In nitrogen atmosphere, 780 g (6.33 mol) of thionyl chloride was added to 1300 g (4.87 mol) of the 6-bromo-5,5,6,6-tetrafluorohexanoic acid obtained as discussed above, followed by stirring at 50° C. for 4 hours. Then distillation was conducted under reduced pressure thereby obtaining 1223 g of the objective 6-bromo-5,5,6,6-tetrafluorohexanoyl chloride in the form of a light yellow liquid (88% yield, 91% GC purity).

Provenance & Evidence