(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester → tert-butyl (3S)-1-(1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-yl(methyl)carbamate

Participants

Reaction Steps

Prepared as described in Example 1, Step C, using 1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl trifluoromethanesulfonate (1.50 g, 4.37 mmol) and (S)-tert-butyl methyl(pyrrolidin-3-yl)carbamate (1.2 g, 6.11 mmol) to afford tert-butyl (3S)-1-(1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-yl(methyl)carbamate (1.15 g, 67%).

Provenance & Evidence