Hydrochloric Acid → HCID 70983850, compound

Participants

Reaction Steps

tert-Butyl (3S)-1-(2,2,2-trifluoro-1-(3-(7-isobutyramido quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (56 mg, 0.094 mmol) was weighed into a 100 mL 1 neck round bottom flask, and dissolve in 5 mL of chloroform, followed by addition of HCl (937 μL, 3.7 mmol). The reaction was then allowed to stir at ambient temperature for 1 hour, at which time the deprotection was complete and light yellow precipitate formed. The reaction was concentrated under vacuum, affording N-(2-(6-(1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-7-yl)isobutyramide (32 mg, 69% yield) as a light yellow semi-solid. LCMS APCI (+) m/z 498.2 (M+H).

Provenance & Evidence