Potassium Phosphate, Tribasic → HCID 70984209, compound

Participants

Reaction Steps

A solution of 8-bromo-7-fluoro-2-methylquinoline (1.00 g, 4.17 mmol), Pd(OAc)2 (0.047 g, 0.21 mmol), P(Cy)3 (0.13 g, 0.46 mmol), K3PO4 (3.09 g, 14.6 mmol) and cyclopropylboronic acid (0.72 g, 8.33 mmol) in toluene (20 mL) and water (2 mL) was stirred at 100° C. for 8 hours. After cooling to ambient temperature, ethyl acetate (20 mL) and water (5 mL) were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (3:1 hexane/DCM) to give 8-cyclopropyl-7-fluoro-2-methylquinoline (0.78 g, 92.7%) as an oil.

Provenance & Evidence