Water → HCID 70983053, compound

Participants

Reaction Steps

To a solution of 7-bromo-2-methylquinolin-8-ol (4.10 g, 14.64 mmol) and Cs2CO3 (11.92 g, 36.59 mmol) in NMP (20 mL) was added iodomethane (1.01 mL, 16.10 mmol) at 0° C. The reaction was warmed to ambient temperature and stirred at ambient temperature for 40 minutes. Water (30 mL) was and added and extracted with DCM (30 mL), dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (DCM) to give 7-bromo-8-methoxy-2-methylquinoline (3.62 g, 91.23%) as an oil.

Provenance & Evidence