Carbamate → tert-butyl 2-fluoroethyl((S)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-yl)carbamate

Participants

Reaction Steps

Prepared as described in Example 9B, Step F, using tert-butyl 2-fluoroethyl((S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-yl)carbamate (0.10 g, 0.237 mmol) in place of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-yl)carbamate and using 8-isopropoxyquinoline-2-carbaldehyde (0.051 g, 0.237 mmol) in place of 8-methoxyquinoline-2-carbaldehyde. LCMS APCI (+) m/z 617 (M+H).

Provenance & Evidence