Potassium Phosphate, Tribasic → HCID 70917093, compound

Participants

Reaction Steps

A solution of 2-bromo-3-nitrobenzoic acid (1.17 g, 4.28 mmol), Pd(OAc)2 (0.048 g, 0.21 mmol), P(Cy)3 (0.132 g, 0.471 mmol), K3PO4 (3.18 g, 15.0 mmol) and cyclopropylboronic acid (0.735 g, 8.56 mmol) in toluene (4 mL) and water (1 mL) was stirred at 100° C. for 6 hours. After cooling to ambient temperature, ethyl acetate (20 mL) and water (5 mL) were added. The aqueous layer was separated and acidified with saturated potassium hydrogen sulfate to about pH 3-4. The resulting solid was collected by filtration to give 2-cyclopropyl-3-nitrobenzoic acid (0.63 g, 71.0%) as a solid.

Provenance & Evidence