HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → HCID 70983812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 70983733 | HCID 70983733 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70983812 | HCID 70983812 | 53.1% |
Reaction Steps
To a solution of 8-cyclopropyl-2-methylquinoline-7-carboxylic acid (0.050 g, 0.220 mmol) and 2-methylpropan-2-amine (0.116 mL, 1.10 mmol) in DMF (1 mL) was added HATU (0.125 g, 0.33 mmol) at ambient temperature and the reaction mixture was stirred at ambient temperature for 1 hour. The reaction mixture was purified directly by C-18 reverse phase flash chromatography (Biotage SP4 unit, C-18 25M column, 0-90% CH3CN/water gradient; 25 column volumes) to give N-tert-butyl-8-cyclopropyl-2-methylquinoline-7-carboxamide (0.033 g, 53.1%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889704B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-fc6c1753c1ea450ebe847cb2124b2ae9 |
| Source note | uspto-grants-2014_11 |