(S)-tert-butyl 2-tert-butoxyethyl(pyrrolidin-3-yl)carbamate → tert-butyl 2-tert-butoxyethyl((S)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-yl)carbamate

Participants

Reaction Steps

Prepared as described in Example 9B, Step D, using (S)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl trifluoromethanesulfonate (1.50 g, 4.37 mmol) and (S)-tert-butyl 2-tert-butoxyethyl(pyrrolidin-3-yl)carbamate (2.0 g, 6.98 mmol) in place of (S)-tert-butyl pyrrolidin-3-ylcarbamate (1.69 g, 81%)

Provenance & Evidence