HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Fluoro-2-methylquinolin-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 6-Fluoro-7-methoxy-2-methylquinoline | HCID 86707442 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 6-Fluoro-2-methylquinolin-7-ol | HCID 136338075 | 133.7% |
Reaction Steps
6-Fluoro-7-methoxy-2-methylquinoline (5.2 g, 19 mmol) was heated to reflux in 48% aqueous HBr for 48 hours. After cooling, the reaction was basified (pH 8) by addition of NH4OH. The resulting solid was filtered, washed with water and dried to yield 6-fluoro-2-methylquinolin-7-ol (4.5 g, 93% yield) as a black solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889704B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-be71dbd7ade54710992c9e16f73af80b |
| Source note | uspto-grants-2014_11 |