Hydrogen Bromide → HCID 86707478, compound

Participants

Reaction Steps

A solution of 8-cyclopropyl-7-methoxy-2-methylquinoline (0.53 g, 2.5 mmol) in hydrobromic acid (48%; 9.9 mL, 2.5 mmol) was heated at reflux for 3 days. After cooling, the reaction mixture was neutralized to pH 8 by addition of ammonium hydroxide and extracted with dichloromethane (3×20 mL). The combined organic extracts were washed with water, dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification by reverse phase chromatography on C18 (0-100% acetonitrile/water) afforded the title compound (0.39 g, 79%).

Provenance & Evidence