Ammonium formate → HCID 53641593, compound

Participants

Reaction Steps

A solution of ethyl 1-benzyl-3-(fluoromethyl)pyrrolidine-3-carboxylate (2.98 g, 11.2 mmol) and ammonium formate (3.54 g, 56.2 mmol) in ethanol (100 mL) was flushed with nitrogen for 15 minutes. 10% Pd/C (1.2 g, 1.12 mmol) was added and the mixture heated at reflux for 30 minutes. The reaction mixture was cooled to ambient temperature, filtered through a pad of Celite, washing with ethanol (50 mL). The filtrate was concentrated under reduced pressure to afford ethyl 3-(fluoromethyl)pyrrolidine-3-carboxylate (1.86 g, 95%).

Provenance & Evidence