tert-Butyl (3-(fluoromethyl)pyrrolidin-3-yl)carbamate → tert-butyl 1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-3-(fluoromethyl)pyrrolidin-3-ylcarbamate

Participants

Reaction Steps

Prepared as described in Example 9B using (S)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl trifluoromethanesulfonate (1.10 g, 3.20 mmol) and tert-butyl 3-(fluoromethyl)pyrrolidin-3-ylcarbamate (0.70 g, 3.21 mmol) in place of (S)-tert-butyl pyrrolidin-3-ylcarbamate in Step D (1.03 g, 78%).

Provenance & Evidence