HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Isopropoxyquinoline-2-carbaldehyde → tert-butyl 3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Isopropoxyquinoline-2-carbaldehyde | HCID 82241822 | — |
| Reactant | tert-butyl 3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate | HCID 86707490 | — |
| Product | tert-butyl 3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate | HCID 86707489 | — |
Reaction Steps
Prepared as described in Example 9B using tert-butyl 3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate in place of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidine-3-ylcarbamate and substituting 8-isopropoxyquinoline-2-carbaldehyde in Step F. LCMS APCI (+) m/z 603 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889704B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-cd547640e4274848972b49ed2f21d843 |
| Source note | uspto-grants-2014_11 |