HCID 70983925, compound → HCID 136338076, compound

Participants

Reaction Steps

(S)-1-((R)-1-(3-(7-(cyclopropylmethoxy)-6-fluoroquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (Example 134; 50 mg, 0.1 mmol) was heated to 60° C. in 6N HCl in IPA for 3 days. After concentration, the residue was dissolve in 1 mL of MeOH then added to 2N HCl in ether. The resulting solid was dried under high vacuum to yield 2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoro quinolin-7-ol hydrochloride (39 mg, 87% yield) as a solid. LCMS APCI (+) m/z 447 (M+H).

Provenance & Evidence