HCID 86707503, compound → HCID 136338077, compound

Participants

Reaction Steps

(S)-1-((R)-1-(3-(8-(cyclopropylmethoxy)-6-fluoroquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (Example 158; 200 mg, 0.400 mmol) was stirred in 5-6N HCl (2 mL) in IPA in a sealed tube at 60° C. for 14 hours. The reaction mixture was concentrated under reduced pressure to provide 2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-ol hydrochloride (128 mg, 71.8% yield) as a solid. LCMS APCI (+) m/z 447 (M+H).

Provenance & Evidence