2-{4-[4-Pyridin-4-YL-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-YL]-phenoxymethyl}-quinoline → 4-[3-(4-Benzyloxy-2-fluoro-phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-pyridine

HRID 33902Notes

Reaction equation

HRID 33902 reaction equation
N1C=CC(C2C(C3C=CC(OCC4C=CC5C(=CC=CC=5)N=4)=CC=3)=NN([CH2:12][C:13]([F:16])([F:15])[F:14])C=2)=CC=1.[CH2:35]([O:42][C:43]1[CH:48]=[CH:47][C:46]([C:49]2[C:53]([C:54]3[CH:59]=[CH:58][N:57]=[CH:56][CH:55]=3)=[CH:52][NH:51][N:50]=2)=[C:45]([F:60])[CH:44]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][C:43]1[CH:48]=[CH:47][C:46]([C:49]2[C:53]([C:54]3[CH:59]=[CH:58][N:57]=[CH:56][CH:55]=3)=[CH:52][N:51]([CH2:12][C:13]([F:16])([F:15])[F:14])[N:50]=2)=[C:45]([F:60])[CH:44]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

3

Reactant 2

HCID 116482762-{4-[4-Pyridin-4-YL-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-YL]-phenoxymethyl}-quinolineHCID 178505957HCID 178505957, compound

Product 1

HCID 685753054-[3-(4-Benzyloxy-2-fluoro-phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-pyridine

Procedure

Following the procedure for the preparation of 2-{4-[-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline but substituting 4-[3-(4-Benzyloxy-2-fluoro-phenyl)-1H-pyrazol4-yl]-pyridine provided the title compound. MS: (M+H m/z=428.4).

Sources & evidence

ORD record
ord-34b434ddbe57417ab76e5ffe3e6f0424
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Reaction notes

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