tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → HCID 86707515, compound

HRID 339020Notes

Reaction equation

HRID 339020 reaction equation
[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[CH3:27][C:28]1[C:29]([C:40]2[CH:41]=[N:42][N:43]([CH3:45])[CH:44]=2)=[CH:30][CH:31]=[C:32]2[C:37]=1[N:36]=[C:35]([CH:38]=O)[CH:34]=[CH:33]2>>[F:26][C:2]([F:1])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH2:17])[CH2:13]1)[C:4]1[CH:9]=[CH:8][C:7]2[N:6]([C:38]([C:35]3[CH:34]=[CH:33][C:32]4[C:37](=[C:28]([CH3:27])[C:29]([C:40]5[CH:41]=[N:42][N:43]([CH3:45])[CH:44]=5)=[CH:30][CH:31]=4)[N:36]=3)=[N:11][N:10]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 86707516HCID 86707516, compound

Product 1

HCID 86707515HCID 86707515, compound

Procedure

Prepared as described in Example 9B, Step F, using tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate and 8-methyl-7-(1-methyl-1H-pyrazol-4-yl)quinoline-2-carbaldehyde. LCMS APCI (+) m/z 507 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a7f8f41382be4629b6af3951c858c3b7
Source dataset
uspto-grants-2014_11
Patent number
US08889704B2

Reaction notes

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