Hydrochloric Acid → HCID 71004817, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (0.900 g, 1.57 mmol) in DCM (8 mL) was added 4M HCl in dioxane (2 mL) and the reaction stirred for 2.5 hours. The reaction was diluted DCM (100 mL) and washed with saturated Na2CO3 (25 mL), dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by normal phase chromatography (5% [10% NH4OH]/DCM) to give (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (0.690 g, 1.45 mmol, 92.8% yield) MS APCI (+) m/z 475 (M+1) detected.

Provenance & Evidence