Hydrochloric Acid → HCID 86707530, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(2-hydroxyethoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (0.40 g, 0.70 mmol) in dichloromethane (1 mL) was added hydrochloric acid (5-6M in 2-propanol; 7.0 mL, 0.61 mmol). The reaction mixture was stirred at ambient temperature for 30 minutes. The solvent was removed under reduced pressure, and the resulting solid was suspended in acetonitrile (3 mL) and stirred at ambient temperature for 5 minutes. The resulting solid was collected by vacuum filtration to give the title compound (0.38 g, 99%). LCMS APCI (+) m/z 473 (M+H).

Provenance & Evidence